ea0094op4.1 | Thyroid | SFEBES2023
Yang Wei
, Palazzo Fausto
, Tolley Neil
, Dimarco Aimee
, Brady Angela
, Tan Tricia
Introduction: Phosphatase and tensin homolog gene (PTEN) gene encodes a lipid phosphatase that plays a central role in cell-cycle processes. PTEN hamartoma tumour syndrome (PHTS), caused by the mutation of the PTEN gene, is a diverse multi-system disorder. PHTS is characterised by the hamartomatous growths, increased risk of breast, thyroid, and renal cancers. In terms of thyroid presentation of PHTS, there is up to 75% risk of multinodular goitre and the life...